ProSci

KCNQ2 Antibody

Product Code:
 
PSI-28-294
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Canine (dog)
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
For short periods of storage (days) store at 4˚C. For longer periods of storage, store KCNQ2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
1 / 3
Antibody used in WB on Human Jurkat 0.2-1 ug/ml.
2 / 3
3 / 3
Antibody used in IHC on Human brain at 5 ug/ml.
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Antibody used in WB on Human Jurkat 0.2-1 ug/ml.
Antibody used in IHC on Human brain at 5 ug/ml.

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PSI-28-294-100ul100ul£662.00
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This product comes from: United States.
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Further Information

Additional Names:
KCNQ2, BFNC, EBN, EBN1, ENB1, HNSPC, KCNA11, KV7.2, KVEBN1, BFNS1, EIEE7
Application Note:
KCNQ2 antibody can be used for detection of KCNQ2 by ELISA at 1:62500. KCNQ2 antibody can be used for detection of KCNQ2 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by KCNQ2 and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Background References:
  • Soldovieri, M.V., (2006) J. Biol. Chem. 281 (1), 418-428.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KCNQ2.
NCBI Gene ID #:
3785
NCBI Official Name:
potassium voltage-gated channel, KQT-like subfamily, member 2
NCBI Official Symbol:
KCNQ2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa, 93 kDa, 94 kDa, 96 kDa, 93 kDa
Protein Accession #:
NP_742107
Protein GI Number:
26051268
Purification:
Antibody is purified by peptide affinity chromatography method.
Research Area:
Membrane
Swissprot #:
Q53Y30
User NOte:
Optimal dilutions for each application to be determined by the researcher.