Further Information
ABL, JTK7, p150, c-ABL, v-abl, c-ABL1, bcr/abl, MAPKAPK1A, RSK1, ABL
Western Blot: 1:500~1:1000
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
- Wang, J. Y. et al. (2000) Oncogene 19, 5643-5650. Danial, N. N. et al. (2000) Oncogene 19, 2523-2531. Brasher, B. B. et al. (2000) J. Biol. Chem. 275, 35631-35637. Pluk, H. et al. (2002) Cell 108, 247-259.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
ABL1/2 (Ab-393/429) antibody was raised against a peptide sequence around aa.391~395/427~431 (D-T-Y-T-A) derived from ABL1/2 .
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c-abl oncogene 1, non-receptor tyrosine kinase / c-abl oncogene 2, non-receptor tyrosine kinase
ABL1 ABL2
This antibody was raised against a peptide sequence around aa.391~395/427~431 (D-T-Y-T-A) derived from ABL1/2
Liquid
PREDICTED MOLECULAR WEIGHT:
135, 210 kDa
NP_005148.2 / NP_001129472.1
62362414 / 209862772
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Cell Cycle
This antibody detects endogenous levels of total ABL1/2 protein.
P00519 P42684