Further Information
AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, Nrage, AAA
Western Blot: 1:500~1:1000
APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
- Hung, A. Y. and Selkoe, D. J. (1994) EMBO J. 13, 534-542. Suzuki, T. et al. (1994) EMBO J. 13, 1114-1122Ando, K. et al. (1999) J. Neurosci. 19, 4421-4427. Iijima, K. I. et al. (2000) J. Neurochem. 75, 1085-1091
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
APP (Phospho-668) antibody was raised against a peptide sequence around phosphorylation site of threonine 668 (A-V-T (p) -P-E) derived from Human APP.
Phospho-Specific
351
amyloid beta (A4) precursor protein
APP
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
100 - 140 kDa
NP_000475.1
4502167
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Phospho-Specific,Neuroscience
This antibody detects endogenous level of APP only when phosphorylated at threonine 668.
P05067?