Antibody Clonality:
Polyclonal
Applications:- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
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![Western blot analysis of lysed extracts from HT29 and HeLa cells using FAK (Ab-576/577). Western blot analysis of lysed extracts from HT29 and HeLa cells using FAK (Ab-576/577).](https://www.prosci-inc.com/static-images/79-433.jpg)
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![Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using FAK (Ab-576/577). Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using FAK (Ab-576/577).](https://www.prosci-inc.com/static-images/79-433a.jpg)
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
FAK, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, JTK2, TKF, FADK 1, PTK2
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
- Parsons, J. T. et al. (2000) Oncogene 19, 5606-5613. Schaller, M. D. et al. (1994) Mol. Cell. Biol. 14, 1680-1688. Chen, H. C. et al. (1996) J. Biol. Chem. 271, 26329-26334. Calalb, M. B. et al. (1995) Mol. Cell. Biol. 15, 954-963.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
FAK (Ab-576/577) antibody was raised against a peptide sequence around aa.574~578/575~579 (T-Y-Y-K-A) derived from Human FAK.
5747
protein tyrosine kinase 2
PTK2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
125 kDa
NP_005598.3
27886593
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Other
This antibody detects endogenous level of total FAK protein.
Q05397