ProSci

MEK5 Antibody

Product Code:
 
PSI-79-516
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
1 / 1
Western blot analysis of lysed extracts from Rat and Mouse brain tissue using MEK5 (phospho-Ser311/ Thr315).
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Western blot analysis of lysed extracts from Rat and Mouse brain tissue using MEK5 (phospho-Ser311/ Thr315).

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PSI-79-516-0.1mg0.1mg£488.00
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Further Information

Additional Names:
Mek5, CDC2, CDC28A, CDKN1, P34CDC2, Map2k5
Application Note:
Western Blot: 1:500~1:1000
Background:
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
Background References:
  • English J. M., Vanderbilt C. A., Xu S., Marcus S., Cobb M. H. J. Biol. Chem. 270:28897-28902 (1995)
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MEK5 (phospho-Ser311/ Thr315) antibody was raised against a peptide sequence around phosphorylation site of Serine 311 and threonine 315 (V-N-S (p) I-A-K-T (p) -Y-V) derived from Rat MEK5.
Modifications:
Phospho-Specific
NCBI Gene ID #:
29568
NCBI Official Name:
mitogen activated protein kinase kinase 5
NCBI Official Symbol:
Map2k5
NCBI Organism:
Rattus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
46 kDa
Protein Accession #:
NP_001029159.1
Protein GI Number:
77157802
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of MEK5 only when phosphorylated at serine 311 or threonine 315.
Swissprot #:
Q62862