Further Information
p85, AGM7, GRB1, p85-ALPHA, LHR, MDU2, MDU3, MIC4, PI3-kinase p85 subunit alpha, PtdIns-3-kinase p85-alpha
Western Blot: 1:500~1:1000
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1./Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
- Stoyanov, B. et al. (1995) Science 269, 690-3. Simpson, L. and Parsons, R. (2001) Exp Cell Res 264, 29-41. Neri, L. M. et al. (2002) Biochim Biophys Acta 1584, 73-80.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
PI3K P85 (phospho-Tyr467) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 467 (L-Y (p) -E-E-Y) derived from Human PI3K P85.
Phospho-Specific
5295
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
85 kDa
NP_852556.2 / NP_001107644.1 / NP_005018.1
32455252 / 166795247 / 4826908
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Phospho-Specific
This antibody detects endogenous level of total PI3K P85 only when phosphorylated at tyrosine 467.
P27986 Q92569 O00459