ProSci

C3 Antibody

Product Code:
 
PSI-XW-7061
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Chicken
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
 
C3 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Direct ELISA test (x axis: protein concentration in ug/ml; y axis: absorbance at 405 nm). Human plasma C3 protein was used as test antigen with XW-7061 at a concentration of 0.1 ug/ml.
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Direct ELISA test (x axis: protein concentration in ug/ml; y axis: absorbance at 405 nm). Human plasma C3 protein was used as test antigen with XW-7061 at a concentration of 0.1 ug/ml.

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CodeSizePrice
PSI-XW-7061-0.05mg0.05mg£765.00
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Further Information

Additional Names:
CPAMD1, Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p,
Application Note:
C3 antibody can be used for the detection of C3 by Western blot, ELISA, may also work for IHC and ICC.
Background:
Human complement component C3. Complement C3 contains two chains linked by a disulfide bond. Its activation by a C3 convertase releases the C3a anaphylatoxin from the amino end of the α chain and generates C3b, which associates with the Bb fragment of complement factor B to form the alternative-complement-pathway C3/C5 convertase.C3a anaphylatoxin is a vasoactive peptide and a mediator of inflammation. C3b, with its highly reactive thiol group, binds to the surface of foreign particles and facilitates phagocytosis. It binds to complement C5 and renders it susceptible to proteolysis by the classical-complement-pathway C3/C5 convertase. The activity of C3b is regulated by proteolytic cleavage involving factors H and I. Its degradation products can also be biologically active.
Background References:
  • de Bruijn,M. H. and Fey,G. H. Human complement component C3: cDNA coding sequence and derived primary structure. Proc. Natl. Acad. Sci. U. S. A. 82 (3), 708-712 (1985).
Buffer:
Phosphate-Buffered Saline. No preservatives added.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
plasma protein
NCBI Gene ID #:
718
NCBI Official Name:
complement component 3
NCBI Official Symbol:
C3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
187.2 kDa (calculated)
Protein Accession #:
NP_000055.1
Protein GI Number:
4557385
Purification:
Antigen affinity-purified
Research Area:
Signal Transduction
Swissprot #:
P01024
User NOte:
Optimal dilutions for each application to be determined by the researcher.