ProSci

SPEN Antibody

Product Code:
 
PSI-46-426
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Caprine (Goat)
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Storage:
 
Aliquot and store at -20˚C. Minimize freezing and thawing.
 

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CodeSizePrice
PSI-46-426-0.1mg0.1mg£505.00
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Further Information

Additional Names:
SPEN, spen homolog, transcriptional regulator (Drosophila) , KIAA0929, MINT, RP1-134O19.1, SHARP, Msx2 interacting nuclear target (MINT) homolog, OTTHUMP00000044600, SMART/HDAC1 associated repressor protein, nuclear receptor transcription cofactor spen homolog, transcriptional regulator
Application Note:
Peptide ELISA: antibody detection limit dilution 1:4000.Western Blot:Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as large as the calculated size of approx. 402kDa according to NP_055816.2. Therefore we cannot recommend an optimal concentration and the product is investigative grade. We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? Have any further splice variants/modified forms been reported?
Background References:
  • Hiriart E, Gruffat H, Buisson M, Mikaelian I, Keppler S, Meresse P, Mercher T, Bernard OA, Sergeant A, Manet E. Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. J Biol Chem. 2005 Nov 4;280(44):36935-45. Epub 2005 Aug 29.
Buffer:
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20?C. Minimize freezing and thawing.
Concentration:
500 ug/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Expected Species Reactivity based on sequence homology: Human
Immunogen:
The immunogen for this antibody is: C-DSEGKMDDKKEDHKE
NCBI Gene ID #:
23013
NCBI Official Name:
spen family transcriptional repressor
NCBI Official Symbol:
SPEN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_055816.2
Protein GI Number:
14790190
Purification:
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Research Area:
Cancer
Swissprot #:
Q96T58