Further Information
MAP2K2, MAPKK2, MEK2, MKK2, PRKMK2, CFC4
MAP2K2 antibody can be used for detection of MAP2K2 by ELISA at 1:312500. MAP2K2 antibody can be used for detection of MAP2K2 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
- Adjei, A.A., (2008) J. Clin. Oncol. 26 (13), 2139-2146.
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MAP2K2.
5605
mitogen-activated protein kinase kinase 2
MAP2K2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
NP_109587
13489054
Antibody is purified by peptide affinity chromatography method.
Cancer ,Signal Transduction
P36507
Optimal dilutions for each application to be determined by the researcher.