Further Information
RCAN1, ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
RCAN1 antibody can be used for detection of RCAN1 by ELISA at 1:312500. RCAN1 antibody can be used for detection of RCAN1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
- Riper, D.V., (2008) Arch. Biochem. Biophys. 472 (1), 43-50.
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RCAN1.
1827
regulator of calcineurin 1
RCAN1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
28 kDa
NP_004405
33620725
Antibody is purified by peptide affinity chromatography method.
Transcription ,Cancer ,Signal Transduction ,Immunology ,Primary ///Neuroscience ,
P53805
Optimal dilutions for each application to be determined by the researcher.