Chimerigen

CD278 [ICOS] (human):Fc (mouse) (rec.)

Product Code:
 
CHI-HF-211ICOS
Product Group:
 
Recombinant Proteins
Supplier:
 
Chimerigen
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
BLUE ICE
Storage:
 
-20°C
 

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CHI-HF-211ICOS-C100100 ug£385.00
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Further Information

Alternate Names/Synonyms:
ICOS; Inducible T Cell Costimulator; CRP1; CD28-related Protein-1; AILIM
Biological Activity:
Measured by its ability to inhibit human T cell proliferation induced by CD275 [B7-H2] (human):Fc (human) (rec.) (Prod. No. CHI-HF-210B7H2) in the presence of anti-CD3.
EClass:
32160000
Endotoxin:
<0.06EU/µg protein (LAL test; Lonza).
Form (Short):
solid
Formulation:
Lyophilized from 0.2µm-filtered solution in PBS.
Handling Advice:
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Protein. The extracellular domain of human CD278 [ICOS] (aa 21-139) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/µg protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. Purity: >98% (SDS-PAGE). CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
NCBI, Uniprot Number:
NP_036224.1
Package Type:
Plastic Vial
Product Description:
CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
Purity:
>98% (SDS-PAGE)
Sequence:
The extracellular domain of human CD278 [ICOS] (aa 21-139) is fused to the N-terminus of the Fc region of mouse IgG2a.
Source / Host:
CHO cells
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.