ProSci

MALT1 Antibody

Product Code:
 
PSI-8097
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
MALT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
1 / 3
Western blot analysis of MALT1 in EL4 cell lysate with MALT1 antibody at (A) 1 and (2) μg/ml.
2 / 3
Immunohistochemistry of MALT1 in human spleen tissue with MALT1 antibody at 5 μg/mL.
3 / 3
Immunofluorescence of MALT1 in human spleen tissue with MALT1 antibody at 20 μg/mL.
❮❯

Western blot analysis of MALT1 in EL4 cell lysate with MALT1 antibody at (A) 1 and (2) μg/ml.
Immunohistochemistry of MALT1 in human spleen tissue with MALT1 antibody at 5 μg/mL.
Immunofluorescence of MALT1 in human spleen tissue with MALT1 antibody at 20 μg/mL.

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CodeSizePrice
PSI-8097-0.02mg0.02mg£150.00
Quantity:
PSI-8097-0.1mg0.1mg£449.00
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Further Information

Additional Names:
Mucosa associated lymphoid tissue lymphoma translocation 1, IMD12, MLT, MLT1
Application Note:
MALT1 antibody can be used for detection of MALT1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
MALT1 was initially identified as a novel gene that was recurrently rearranged in t(11;18)(q21;q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1). MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2,3). MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4).
Background References:
  • Dielamm J, Baens M, Wlodarska I, et al. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 1999; 93:3601-9.
  • Lin X and Wang D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin. Immunol. 2004; 16:429-35.
  • Rosebeck S, Rehman AO, Lucas PC, et al. From MALT lymphoma to the CBM signalsome: three decades of discovery. Cell Cycle 2011; 10:2485-96.
  • Staal J, Bekaert T, and Beyaert R. Regulation of NF-kB signaling by caspases and MALT1 paracaspase. Cell Res. 21:40-54.
Buffer:
MALT1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MALT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MALT1.

The immunogen is located within amino acids 630 - 680 of MALT1.
NCBI Gene ID #:
10892
NCBI Official Name:
mucosa associated lymphoid tissue lymphoma translocation gene 1
NCBI Official Symbol:
MALT1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 91 kDa

Observed: 96 kDa
Protein Accession #:
NP_006776
Protein GI Number:
5803078
Purification:
MALT1 antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Immunology
SPECIFICITY:
MALT1 antibody is human, mouse and rat reactive. At least two isoforms of MALT1 are known to exist; this antibody will detect both isoforms.
Swissprot #:
Q9UDY8
User NOte:
Optimal dilutions for each application to be determined by the researcher.