ProSci

PTRF 1 Antibody

Product Code:
 
PSI-39-859
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
 

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PSI-39-859-0.1mg0.1mg£782.00
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Further Information

Additional Names:
2310075E07Rik, AW546441, Cavin, MGC118550, Cavin 1, CAVIN1, CGL4, FKSG13, FLJ90031, OTTMUSP00000002049, polymerase I and transcript release factor, RNA polymerase I and transcript release factor, RP23-279L23.6, TTF I interacting 12, CAVIN, cavin-1,
Application Note:
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Background:
Cavin 1-PTRF has been shown to be an essential component of caveolae. Cavin 1-PTRF appear to be recruited to membrane domains containing PS, cholesterol and oligomerized caveolins. Binding of Cavin 1-PTRF to these domains stabilizes the membrane curvature to produce the classic flask shape of caveolae. Disassembly of Cavin 1- PTRF releases caveolar components, including caveolins into the plasma membrane. Succinctly it appears that Cavin 1-PTRF regulates caveola structure and function.
Background References:
  • Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, Walser P, Abankwa D, Oorschot VM, Martin S, Hancock JF, Parton RG., PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function., Cell. 2008 Jan 11;132(1):23-4
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
A synthetic peptide corresponding to the C terminal region.
NCBI Gene ID #:
284119
NCBI Official Name:
polymerase I and transcript release factor
NCBI Official Symbol:
APP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
BAG60757
Protein GI Number:
56749614
Purification:
Affinity Purified
Research Area:
Homeostasis
Swissprot #:
Q6NZI2
User NOte:
Optimal dilutions for each application to be determined by the researcher.