ProSci

Neurturin Recombinant Protein

Product Code:
 
PSI-40-500
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized Neurturin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Neurturin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protei
 

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CodeSizePrice
PSI-40-500-0.005mg0.005mg£300.00
Quantity:
PSI-40-500-0.02mg0.02mg£428.00
Quantity:
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This product comes from: United States.
Typical lead time: 14-21 working days.
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Further Information

Additional Names:
NTN, Neurturin
Background:
Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRalpha2. The functional form of human Neurturin is a disulfide-linked homodimer, of two 11.8 kDa polypeptide monomers (206 total amino acid residues). Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
Biological Activity:
Human Neurturin at a concentration of 100 ng/mL will support the survival of 65% of newborn rat sympathetic neurons.
NCBI Gene ID #:
4902
NCBI Official Name:
neurturin
NCBI Official Symbol:
NRTN
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_004549.1
Protein GI Number:
4758826
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q99748

Documents