ProSci

NOV Recombinant Protein

Product Code:
 
PSI-40-222
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized NOV recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted NOV is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing
 

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CodeSizePrice
PSI-40-222-0.005mg0.005mg£300.00
Quantity:
PSI-40-222-0.02mg0.02mg£428.00
Quantity:
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Further Information

Additional Names:
CCN3, NOVh, IBP-9, IGFBP9, IGFBP-9, CCN3, NOVH, Protein NOV homolog, CCN family member 3, NovH
Background:
NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm?s tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant human NOV is a 36.2 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).
Biological Activity:
Biological activity was determined by a cell proliferation assay using BALB/c 3T3 cells. The expected ED50 for this effect is 1.0 - 2.0 μg/mL
NCBI Gene ID #:
4856
NCBI Official Name:
nephroblastoma overexpressed
NCBI Official Symbol:
NOV
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_002505.1
Protein GI Number:
4505423
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P48745

Documents