ProSci

Soluble CD14 Recombinant Protein

Product Code:
 
PSI-40-198
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized Soluble CD14 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Soluble CD14 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any
 

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CodeSizePrice
PSI-40-198-0.01mg0.01mg£300.00
Quantity:
PSI-40-198-0.05mg0.05mg£428.00
Quantity:
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Further Information

Additional Names:
Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein
Background:
CD14 is a cell surface anchored glycoprotein that is expressed predominantly by monocytes and tissue macrophages. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappa-β. CD14 also exists in a soluble form, designated as sCD14, which is capable of specifically binding LPS in the extracellular space. Recombinant sCD14 is a 331 amino acid glycoprotein comprising the extracellular portion of the CD14 receptor.
Biological Activity:
Biological activity was determined by the dose dependent activation of NF - kappaB in a RAW264 cell line based reporter system, using a sCD14 concentration range of 20 ng/μL to 200 ng/μL. The NF - kappaB activation is enhanced when the assay is done in the presence of 0.25 ng/μL to 1.0 ng/μL bacterial LPS.
NCBI Gene ID #:
929
NCBI Official Name:
CD14 molecule
NCBI Official Symbol:
CD14
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000582.1
Protein GI Number:
4557417
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P08571

Documents