ProSci

CD3 Antibody [OKT3] (FITC)

Product Code:
 
PSI-76-248
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
MouseIgG2a, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
OKT3
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
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Human peripheral blood lymphocytes were stained with FITC OKT3 with relevant isotype control in Red.
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Human peripheral blood lymphocytes were stained with FITC OKT3 with relevant isotype control in Red.

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PSI-76-248-25tests25tests£264.00
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Further Information

Additional Names:
T3E, TCRE, IMD18, CD3E
Background:
The OKT3 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains gamma, delta, and epsilon chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.
Background References:
  • Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
  • Knapp W(1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
  • Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., ... Jolliffe, L. K. (1994). Humanization of the murine anti-human CD3 monoclonal antibody OKT3.Human Antibodies,5(1), 41-47.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
FITC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
916
NCBI Official Name:
CD3e molecule, epsilon (CD3-TCR complex)
NCBI Official Symbol:
CD3E
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The OKT3 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex.
Swissprot #:
P07766
User NOte:
Optimal dilutions for each application to be determined by the researcher.