ProSci

CD197 Antibody [3D12] (PE)

Product Code:
 
PSI-76-931
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
3D12
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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PSI-76-931-100tests100tests£565.00
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Further Information

Additional Names:
BLR2, EBI1, CCR-7, CD197, CDw197, CMKBR7, CC-CKR-7, CCR7
Background:
The 3D12 monoclonal antibody specifically reacts with human CD197 (CCR7 or EBI-1), a seven-transmembrane G-protein-coupled. It is the receptor for the secondary lymphoid-tissue chemokine (SLC or 6CKine), CCL19, and CCL21. CD197 is expressed on subsets of B and T cells, and mature dendritic cells. The monoclonal 3D12 antibody recognizes the N-terminus of the receptor.
Background References:
  • Gattei, V., Godeas, C., Degan, M., Rossi, F. M., Aldinucci, D., Pinto, A. (1999). Characterization of antiCD138 monoclonal antibodies as tools for investigating the molecular polymorphism of syndecan1 in human lymphoma cells.British journal of haematology,104(1), 152-162.
  • Fitzgerald, M. L., Wang, Z., Park, P. W., Murphy, G., Bernfield, M. (2000). Shedding of syndecan-1 and-4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3sensitive metalloproteinase.The Journal of cell biology,148(4), 811-824.
  • Itoua Maga, R., Lemieux, J., Roy, A., Simard, C., Nron, S. (2014). Flow Cytometry Assessment of In Vitro Generated CD138.BioMed research international,2014.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
1236
NCBI Official Name:
chemokine (C-C motif) receptor 7
NCBI Official Symbol:
CCR7
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology,Chemokines & Cytokines, Growth Factors
SPECIFICITY:
The 3D12 monoclonal antibody specifically reacts with human CD197 (CCR7 or EBI-1), a seven-transmembrane G-protein-coupled.
Swissprot #:
P32248
User NOte:
Optimal dilutions for each application to be determined by the researcher.