CD45 Antibody [30-F11] (FITC)
Antibody Isotype:
Rat IgG2b, kappa
Antibody Clonality:
Monoclonal
Application:
Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
loc, B220, Cd45, L-CA, Ly-5, T200, CD45R, Lyt-4, Ptprc
The 30-F11 monoclonal antibody specifically reacts with all isoforms of CD45 and also with the alloantigens CD45.1 and CD45.2 (LCA). CD45 is a transmembrane glycoprotein, expressed by all the hematopoietic cells, except for platelets and mature erythrocytes, which distinguishes the leukocytes from the non-hematopoietic cells. The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region?s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons.The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction.
- Ledbetter, J. A., Herzenberg, L. A. (1979). Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*.Immunological reviews,47(1), 63-90.
- Thomas, M. L. (1989). The leukocyte common antigen family.Annual review of immunology,7(1), 339-369.
- Simon, D. I., Chen, Z., Seifert, P., Edelman, E. R., Ballantyne, C. M., Rogers, C. (2000). Decreased neointimal formation in Mac-1/mice reveals a role for inflammation in vascular repair after angioplasty.Journal of Clinical Investigation,105(3), 293-300.
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
batch dependent
FITC
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
19264
protein tyrosine phosphatase, receptor type, C
Ptprc
Mus musculus
liquid
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Immunology
The 30-F11 monoclonal antibody specifically reacts with all isoforms of CD45 and also with the alloantigens CD45.1 and CD45.2 (LCA).
P06800
Optimal dilutions for each application to be determined by the researcher.