ProSci

CD29 Antibody [HMb1-1] (PE)

Product Code:
 
PSI-76-796
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Hamster
Antibody Isotype:
 
Armenian Hamster IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
HMb1-1
Regulatory Status:
 
RUO
Target Species:
  • Mouse
  • Rat
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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CodeSizePrice
PSI-76-796-0.1mg0.1mg£469.00
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Further Information

Additional Names:
CD29, Fnrb, gpIIa, Gm9863, AA409975, AA960159, 4633401G24Rik, ENSMUSG00000051907, Itgb1
Background:
The HMb1-1 monoclonal antibody specifically reacts with mouse/rat CD29, a 130 kDA molecule also known as integrin beta 1, GPIIa, and the VLA-beta chain. It is expressed broadly on endothelial cells, epithelial, leukocytes, and smooth muscle. CD29 forms the VLA 1-6 complexes through the non-covalent interaction with the alpha integrins of CD49 a-f. The HMb1-1 antibody is capable of inhibiting T cell proliferation and blocking cell adhesion.
Background References:
  • Ridger, V. C., Wagner, B. E., Wallace, W. A., Hellewell, P. G. (2001). Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation.The Journal of Immunology,166(5), 3484-3490.
  • Noto, K., Kato, K., Okumura, K., Yagita, H. (1995). Identification and functional characterization of mouse CD29 with a mAb.International immunology,7(5), 835-842.
  • Sangaletti, S., Di Carlo, E., Gariboldi, S., Miotti, S., Cappetti, B., Parenza, M., ... Colombo, M. P. (2008). Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis.Cancer research,68(21), 9050-9059.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
16412; 24511
NCBI Official Name:
integrin beta 1 (fibronectin receptor beta)
NCBI Official Symbol:
Itgb1
NCBI Organism:
Mus musculus; Rattus norvegicus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Cancer
SPECIFICITY:
The HMb1-1 monoclonal antibody specifically reacts with mouse/rat CD29, a 130 kDA molecule also known as integrin beta 1, GPIIa, and the VLA-beta chain.
Swissprot #:
P09055
User NOte:
Optimal dilutions for each application to be determined by the researcher.