Antibody Isotype:
Armenian Hamster IgM, kappa
Antibody Clonality:
Monoclonal
Applications:- Flow Cytometry
- Functional Study
Storage:
The product should be stored undiluted at 4°C. Do not freeze.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
IGM, p50, Bp50, GP39, IMD3, TRAP, HIGM1, T-BAM, Tnfrsf5, AI326936, Cd40
The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The HM40-3 antibody blocks the binding of CD40L (CD154) and stimulates B and dendritic cell proliferation.
- Kaneko, Y., Hirose, S., Abe, M., Yagita, H., Okumura, K., Shirai, T. (1996). CD40mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus.European journal of immunology,26(12), 3061-3065.
- Ferlin, W. G., Severinson, E., Strm, L., Heath, A. W., Coffman, R. L., Ferrick, D. A., Howard, M. C. (1996). CD40 signaling induces interleukin4independent IgE switching in vivo.European journal of immunology,26(12), 2911-2915.
- Kashiwada, M., Kaneko, Y., Yagita, H., Okumura, K., Takemori, T. (1996). Activation of mitogenactivated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells.European journal of immunology,26(7), 1451-1458.
Phosphate-buffered aqueous solution, ph7.2.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
21939
CD40 antigen
Cd40
Mus musculus
liquid
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Immunology,Functional Assays
The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50.
P27512
Optimal dilutions for each application to be determined by the researcher.