ProSci

CD28 Antibody [JJ319]

Product Code:
 
PSI-76-743
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
JJ319
Regulatory Status:
 
RUO
Target Species:
 
Rat
Applications:
  • Flow Cytometry
  • Functional Study
Storage:
 
The product should be stored undiluted at 4°C. Do not freeze.
 

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CodeSizePrice
PSI-76-743-0.05mg0.05mg£344.00
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Further Information

Additional Names:
CD28RNA, Cd28
Background:
The JJ319 monoclonal antibody specifically reacts with rat CD28, a 44 kDa glycoprotein member of the immunoglobulin superfamily. CD28 is expressed on alpha/beta TCR+ T cells, some gamma/delta TCR+ T cells and a subset of NK cells. CD28 is a costimulatory receptor required for T cell activation. Its ligands are CD80 (B7-1) and CD86 (B7-2).
Background References:
  • Nandi, D., Gross, J. A., Allison, J. P. (1994). CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells.The Journal of Immunology,152(7), 3361-3369.
  • Gross, J. A., Callas, E. L. E. N. I., Allison, J. P. (1992). Identification and distribution of the costimulatory receptor CD28 in the mouse.The Journal of Immunology,149(2), 380-388.
  • Nishio, M., Spielman, J., Lee, R. K., Nelson, D. L., Podack, E. R. (1996). CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis.The Journal of Immunology,157(10), 4347-4353.
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
25660
NCBI Official Name:
Cd28 molecule
NCBI Official Symbol:
Cd28
NCBI Organism:
Rattus norvegicus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Research Area:
Immunology,Functional Assays
SPECIFICITY:
The JJ319 monoclonal antibody specifically reacts with rat CD28, a 44 kDa glycoprotein member of the immunoglobulin superfamily.
Swissprot #:
P31042
User NOte:
Optimal dilutions for each application to be determined by the researcher.