Further Information
CD36, SCARB3, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, Platelet Glycoprotein 4, glycoprotein IV, gpIV, glycoprotein IIIb, gpIIIb
This recombinant protein can be used for WB. For research use only.
CD36 (Cluster of Differentiation 36) is also known as platelet membrane glycoprotein IV (GPIV), fatty acid translocase (FAT), thrombospondin receptor, collagen receptor, and scavenger receptor class B, member 3 (SRB3), is a member of the class B scavenger receptor family of cell surface proteins. The human CD36 gene encodes a single chain 472 amino acid residue protein containing both an N- and a C-terminal cytoplasmic tail and an extracellular loop.CD36 is found on platelets, erythrocytes, monocytes, differentiated adipocytes, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells. CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands, including long chain fatty acid (LCFA), advanced glycation end products (AGE), thrombospondin-1, oxidized low-density lipoproteins (oxLDLs), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells, beta-amyloid fibrils (fAβ), collagens I and IV, and Plasmodium falciparum infected erythrocytes. CD36 is required for the anti-angiogenic effects of thrombospondin1 In the corneal neovascularization assay. On binding a ligand the protein and ligand are internalized. This internalization is independent of macropinocytosis and occurs by an actin dependent mechanism requiring the activation Src-family kinases, JNK and Rho-family GTPases. CD36 ligands have also been shown to promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
- Husemann, J. et al., 2002, Glia 40:195.
- Armstrong, L and P. Bornstein, 2003, Matrix. Biol. 22:63.
- Collins RF, et al., 2009, J. Biol. Chem. 284 (44): 30288?97.
- Stewart CR, et al., 2010, Nat. Immunol. 11 (2): 155?61.
Measured by its binding ability in a functional ELISA. Immobilized rhCD36 at 2μg/mL (100μL/well) can bind rhTSP2/His with a linear range of 0. 01-1μg/mL.
PBS, pH7.4
His Tag
948
CD36 molecule (thrombospondin receptor)
CD36
Homo sapiens
Lyophilized
Predicted Molecular Weight:
47.5 kDa
NP_001001547.1
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
HEK293 cells
P16671