Further Information
TGFB1, CED, DPD1, LAP, TGFβ1 , TGF-beta
This recombinant protein can be used for WB. For research use only.
Transforming growth factor beta 1 (TGFB1) is also known as TGF-β1, CED, DPD1, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The TGFB1 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGFB1 protein is found throughout the body and plays a role in development before birth, the formation of blood vessels, the regulation of muscle tissue and body fat development, wound healing, and immune system function. TGFB1 is particularly abundant in tissues that make up the skeleton, where it helps regulate bone growth, and in the intricate lattice that forms in the spaces between cells (the extracellular matrix). Within cells, this protein is turned off (inactive) until it receives a chemical signal to become active. TGFB1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGFB1. TGFB1 has been shown to interact with TGF beta receptor 1, LTBP1, YWHAE, EIF3I and Decorin.
- Ghadami M, et al., 2000, Am. J. Hum. Genet. 66 : 143?7.
- Assoian R, et al., 1983, J Biol Chem , 258 (11): 7155?60.
- Derynck R, et al., 1985, Nature 316 (6030): 701?5.
- Letterio J, Roberts A, 1998, Annu Rev Immunol 16: 137?61.
The bio-activity was determined by its ability to inhibit IL-4 induced HT-2 cell proliferation. The ED50<0. 05 ng/mL, corresponding to a specific activity of >2X107 Unit/mg
TFA and acetonitrile
Tag free
21803
transforming growth factor, beta 1
Tgfb1
Mus musculus
Lyophilized
Predicted Molecular Weight:
12.8 kDa (monomer)
P01137-1
>95% as determined by SDS-PAGE.
Less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
HEK293 cells
P01137