ProSci

LTbetaR Antibody [4H8 WH2] (preservative free)

Product Code:
 
PSI-36-101
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
4H8 WH2
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Flow Cytometry
  • Functional Study
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-101-100ug100ug£669.00
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Further Information

Additional Names:
Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3
Application Note:
Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.
Background:
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Buffer:
Liquid. In PBS containing 10% glycerol. Preservative free formulation.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).
NCBI Gene ID #:
17000
NCBI Official Name:
lymphotoxin B receptor
NCBI Official Symbol:
Ltbr
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
1729988
Protein GI Number:
P50284
Purification:
>95% (SDS-PAGE)
Research Area:
Immunology,Innate Immunity,Functional Assays
SPECIFICITY:
Recognizes mouse LTbetaR.
Swissprot #:
P50284
User NOte:
Optimal dilutions for each application to be determined by the researcher.