ProSci

NLRP3/NALP3 Antibody [Cryo-1]

Product Code:
 
PSI-36-099
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2b
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Cryo-1
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-099-100ug100ug£729.00
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Further Information

Additional Names:
NACHT-, LRR- and PYD-containing Protein 3; NLRP3; Cryopyrin; Cold Autoinflammatory Syndrome 1 Protein
Application Note:
Western Blot (see online protocol): (1ug/ml).
Background:
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93).
NCBI Gene ID #:
216799
NCBI Official Name:
NLR family, pyrin domain containing 3
NCBI Official Symbol:
Nlrp3
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
29427844
Protein GI Number:
Q8R4B8
Purification:
>95% (SDS-PAGE)
Research Area:
Innate Immunity
SPECIFICITY:
Recognizes mouse NLRP3/NALP3.
Swissprot #:
Q8R4B8
User NOte:
Optimal dilutions for each application to be determined by the researcher.