ProSci

FGF-23 Recombinant Protein

Product Code:
 
PSI-90-131
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Storage:
 
Working aliquots are stable for up to 3 months when stored at -20˚C.
 

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PSI-90-131-10ug10ug£433.00
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Further Information

Additional Names:
Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor
Application Note:
This recombinant proteins is for research use only.
Background:
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
Biological Activity:
Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
Buffer:
0.2um-filtered solution in PBS.
Fusion Tag:
Fc Tag
NCBI Gene ID #:
64654
NCBI Official Name:
fibroblast growth factor 23
NCBI Official Symbol:
Fgf23
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
Q9EPC2
Protein GI Number:
12083589
Purity:
>90% (SDS-PAGE).

Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9GZV9

Documents