ProSci

Sialate O-Acetylesterase Recombinant Protein

Product Code:
 
PSI-91-729
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
 

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PSI-91-729-0.05mg0.05mg£883.00
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Further Information

Additional Names:
Sialate O-Acetylesterase, H-Lse, Sialic Acid-Specific 9-O-Acetylesterase, SIAE, YSG2
Application Note:
This recombinant protein can be used for biological assays. For research use only.
Background:
Sialate O-Acetylesterase (SIAE) belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. SIAE is widely expressed with high expression levels in the testis, prostate, and colon. SIAE catalyzes N-acetyl-O-acetylneuraminate and H2O to N-acetylneuraminate and acetate. SIAE removes O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. SIAE down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for immunological tolerance. Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.
Buffer:
Supplied as a 0.2 um filtered solution of 20mM TrisHCl,150mM NaCl,10%Glycerol,pH7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Fusion Tag:
C-6 His tag
NCBI Gene ID #:
54414
NCBI Official Name:
sialic acid acetylesterase
NCBI Official Symbol:
SIAE
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Predicted Molecular Weight:
57 kD
Protein Accession #:
Q9HAT2
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
Human Cells
Swissprot #:
Q9HAT2

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