Abnova Corporation

HLA-DQ monoclonal antibody, clone SPM422

Product Code:
 
MAB13077
Product Group:
 
Primary Antibodies
Supplier:
 
Abnova Corporation
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2a, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
SPM422
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Flow Cytometry
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
 
Store at 4°C.
 

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MAB13077-100ug100 ug£488.00
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Further Information

Antigen Target Species:
Human
Form:
Liquid
Gene Alias:
CD|CELIAC1|DQ-A1|FLJ27088|FLJ27328|GSE|HLA-DQA|MGC149527
Gene Description:
major histocompatibility complex, class II, DQ alpha 1
Gene ID:
3117|3118|3119
Gene Name:
HLA-DQA1
Immunogen:
T4-positive CTL clone HG-38.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Product Description:
Mouse monoclonal antibody raised against native human HLA-DQ.
Protein Accession:
P01908;P01909;P01920
Recommend Dilutions:
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
Specificity:
Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. This monoclonal antibody strongly blocks cytotoxicity activity of T4+ cytotoxic T cell clones.
Storage Buffer:
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).