Further Information
CD9 Antibody: CD9 molecule, MIC3, MRP-1, BTCC-1, DRAP-27, TSPAN29, TSPAN-29
CD9 antibody can be used for Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
CD9 Antibody: CD9 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Like other tetraspanins, CD9 is a cell surface glycoproteins play a role in many cellular processes including differentiation, adhesion, and signal transduction (1). CD9 expression plays a critical role in the suppression of cancer cell motility and metastasis. In one study, the knockdown of CD9 expression suppressed the metastatic capacity of human breast cancer cells (2), while other results have shown the opposite effect, suggesting that different proteins associated with CD9 account for its abilities to promote or suppress metastasis (3).
- Murayama Y, Oritani K, and Tsutsui S. Novel CD9-targeted therapies in gastric cancer. World J. Gastroenterol. 2015; 21:3206-13.
- Rappa G, Green TM, Karbanova J, Corbeil D, et al. Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells. Oncotarget 2015; 6:7970-91.
- Zoller M. Tetraspanins: push and pull in suppressing and promoting metastasis. Nat. Rev. Cancer 2009; 9:40-55.
CD9 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Cat: (90%), Bovine: (89%), Mouse: (84%), Rat: (84%), Boar: (78%)
CD9 antibody was raised against a peptide corresponding to 19 amino acids near the center of human CD9.
928
CD9
CD9
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 25 kDa
Observed: 25 kDa
NP_001760
4502693
CD9 Antibody is affinity chromatography purified via peptide column.
Cancer,Cell Cycle
P21926
Optimal dilutions for each application to be determined by the researcher.