Further Information
Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7, USP7, HAUSP
For WB starting dilution is: 1:1000
Hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. Deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.
- Sarkari, F., et al. J. Mol. Biol. 402(5):825-837(2010)
- de Bie, P., et al. Biochem. Biophys. Res. Commun. 400(3):389-395(2010)
- Maertens, G.N., et al. EMBO J. 29(15):2553-2565(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Rat
This USP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-348 amino acids from the Central region of human USP7.
7874
Ubiquitin carboxyl-terminal hydrolase 7
USP7
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
128 kDa
Q93009
212276477
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Cell Cycle,
Q93009
Optimal dilutions for each application to be determined by the researcher.