Further Information
Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Nuclear factor NF-kappa-B p50 subunit, NFKB1
For WB starting dilution is: 1:1000
This gene encodes a 105 kD protein which can undergo
cotranslational processing by the 26S proteasome to produce a 50 kD
protein. The 105 kD protein is a Rel protein-specific transcription
inhibitor and the 50 kD protein is a DNA binding subunit of the
NF-kappa-B (NFKB) protein complex. NFKB is a transcription
regulator that is activated by various intra- and extra-cellular
stimuli such as cytokines, oxidant-free radicals, ultraviolet
irradiation, and bacterial or viral products. Activated NFKB
translocates into the nucleus and stimulates the expression of
genes involved in a wide variety of biological functions.
Inappropriate activation of NFKB has been associated with a number
of inflammatory diseases while persistent inhibition of NFKB leads
to inappropriate immune cell development or delayed cell growth.
Two transcript variants encoding different isoforms have been found
for this gene.
- Beshir, A.B., et al. Cancer Lett. 299(2):137-149(2010)
- Song, C., et al. Virology 407(2):268-280(2010)
- Gonsalves, C., et al. J. Immunol. 185(10):6253-6264(2010)
- Kingeter, L.M., et al. J. Immunol. 185(8):4520-4524(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat
This NFKB(p105) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-937 amino acids from the C-terminal region of human NFKB(p105).
4790
Nuclear factor NF-kappa-B p105 subunit
NFKB1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
105 kDa
P19838
21542418
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Cell Cycle,Immunology,Signal Transduction
P19838
Optimal dilutions for each application to be determined by the researcher.