Further Information
Low-density lipoprotein receptor-related protein 2, LRP-2, Glycoprotein 330, gp330, Megalin, LRP2
For IHC-P starting dilution is: 1:50~100
Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration (1). Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes (2). All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family (3).
- Christensen, E.I., et al., Nat. Rev. Mol. Cell Biol. 3(4):256-266 (2002).
- Hjalm, G., et al., Eur. J. Biochem. 239(1):132-137 (1996).
- Farquhar, M.G., et al., J. Am. Soc. Nephrol. 6(1):35-47 (1995).
- Kounnas, M.Z., et al., J. Biol. Chem. 270(22):13070-13075 (1995).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This LRP2 (Megalin) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4626-4655 amino acids from the C-terminal region of human LRP2 (Megalin).
4036
Low-density lipoprotein receptor-related protein 2
LRP2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
522 kDa
P98164
160332309
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cancer,Cell Cycle,Obesity,Signal Transduction
P98164
Optimal dilutions for each application to be determined by the researcher.