Further Information
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, Iron-sulfur subunit of complex II, Ip, SDHB, SDH, SDH1
For WB starting dilution is: 1:1000
Complex II of the respiratory chain, which is specifically
involved in the oxidation of succinate, carries electrons from FADH
to CoQ. The complex is composed of four nuclear-encoded subunits
and is localized in the mitochondrial inner membrane. The
iron-sulfur subunit is highly conserved and contains three
cysteine-rich clusters which may comprise the iron-sulfur centers
of the enzyme. Sporadic and familial mutations in this gene result
in paragangliomas and pheochromocytoma, and support a link between
mitochondrial dysfunction and tumorigenesis.
- Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Cerecer-Gil, N.Y., et al. Clin. Cancer Res. 16(16):4148-4154(2010)
- Schimke, R.N., et al. Am. J. Med. Genet.152A (6), 1531-1535 (2010) :
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig
This SDHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the C-terminal region of human SDHB.
6390
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
SDHB
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
32 kDa
P21912
20455488
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Cell Cycle,Obesity,Signal Transduction
P21912
Optimal dilutions for each application to be determined by the researcher.