Further Information
TNF receptor-associated factor 4, Cysteine-rich domain associated with RING and Traf domains protein 1, Metastatic lymph node gene 62 protein, MLN 62, RING finger protein 83, TRAF4, CART1, MLN62, RNF83
For WB starting dilution is: 1:1000
This gene encodes a member of the TNF receptor associated
factor (TRAF) family. TRAF proteins are associated with, and
mediate signal transduction from members of the TNF receptor
superfamily. The encoded protein has been shown to interact with
neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR
induced cell death and NF-kappa B activation. This protein has been
found to bind to p47phox, a cytosolic regulatory factor included in
a multi-protein complex known as NAD(P)H oxidase. This protein
thus, is thought to be involved in the oxidative activation of
MAPK8/JNK. Alternatively spliced transcript variants have been
observed but the full-length nature of only one has been
determined.
- Li, S., et al. Mol. Cell. Biochem. 338 (1-2), 11-17 (2010) :
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
- Segat, L., et al. Vaccine 28(10):2201-2206(2010)
- Albers, H.M., et al. Ann. Rheum. Dis. 67(11):1578-1580(2008)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse
This TRAF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 427-455 amino acids from the C-terminal region of human TRAF4.
9618
TNF receptor-associated factor 4
TRAF4
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
54 kDa
Q9BUZ4
30580636
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Cell Cycle,Signal Transduction
Q9BUZ4
Optimal dilutions for each application to be determined by the researcher.