Further Information
Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP contains an extracellular
domain, a single transmembrane segment and two tandem
intracytoplasmic catalytic domains, and thus belongs to receptor
type PTP. This gene is specifically expressed in hematopoietic
cells. This PTP has been shown to be an essential regulator of T-
and B-cell antigen receptor signaling. It functions through either
direct interaction with components of the antigen receptor
complexes, or by activating various Src family kinases required for
the antigen receptor signaling. This PTP also suppresses JAK
kinases, and thus functions as a regulator of cytokine receptor
signaling. Four alternatively spliced transcripts variants of this
gene, which encode distinct isoforms, have been reported. [provided
by RefSeq].
- Heyd, F., et al. Mol. Cell 40(1):126-137(2010)
- Wu, Z., et al. J. Immunol. 185(1):231-238(2010)
- Cui, J., et al. Arthritis Rheum. 62(7):1849-1861(2010)
- Booth, N.J., et al. J. Immunol. 184(8):4317-4326(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This PTPRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the N-terminal region of human PTPRC.
5788
Receptor-type tyrosine-protein phosphatase C
PTPRC
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
147 kDa
P08575
33112650
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Immunology,Neuroscience,Signal Transduction
P08575
Optimal dilutions for each application to be determined by the researcher.