Further Information
Fibroblast growth factor receptor 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
For WB starting dilution is: 1:1000
FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome.
- Jiao, J., et al., Arch. Biochem. Biophys. 410(2):187-200 (2003).
- Fu, L., et al., J. Comp. Neurol. 462(2):265-273 (2003).
- Lundin, L., et al., Exp. Cell Res. 287(1):190-198 (2003).
- Kiselyov, V.V., et al., Structure (Camb.) 11(6):691-701 (2003).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-161 amino acids from human FGFR1.
2260
Fibroblast growth factor receptor 1
FGFR1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
92 kDa
P11362
120046
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Neuroscience,Signal Transduction
P11362
Optimal dilutions for each application to be determined by the researcher.