Further Information
5'-AMP-activated protein kinase catalytic subunit alpha-2, AMPK subunit alpha-2, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, PRKAA2, AMPK, AMPK2
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
The protein encoded by this gene is a catalytic subunit of
the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer
consisting of an alpha catalytic subunit, and non-catalytic beta
and gamma subunits. AMPK is an important energy-sensing enzyme that
monitors cellular energy status. In response to cellular metabolic
stresses, AMPK is activated, and thus phosphorylates and
inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy
beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in
regulating de novo biosynthesis of fatty acid and cholesterol.
Studies of the mouse counterpart suggest that this catalytic
subunit may control whole-body insulin sensitivity and is necessary
for maintaining myocardial energy homeostasis during ischemia.
- Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Jassim, G., et al. Pharmacopsychiatry (2010) In press :
- Bungard, D., et al. Science 329(5996):1201-1205(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat
This PRKAA2 (Thr172) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-173 amino acids from the Central region of human PRKAA2 (Thr172).
5563
5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
62 kDa
P54646
20178276
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Obesity,Neuroscience,Signal Transduction,Autophagy
P54646
Optimal dilutions for each application to be determined by the researcher.