Further Information
Fructose-bisphosphate aldolase B, Liver-type aldolase, ALDOB, ALDB
For WB starting dilution is: 1:1000
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a
tetrameric glycolytic enzyme that catalyzes the reversible
conversion of fructose-1,6-bisphosphate to glyceraldehyde
3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3
aldolase isozymes which are distinguished by their electrophoretic
and catalytic properties. Differences indicate that aldolases A, B,
and C are distinct proteins, the products of a family of related
'housekeeping' genes exhibiting developmentally regulated
expression of the different isozymes. The developing embryo
produces aldolase A, which is produced in even greater amounts in
adult muscle where it can be as much as 5% of total cellular
protein. In adult liver, kidney and intestine, aldolase A
expression is repressed and aldolase B is produced. In brain and
other nervous tissue, aldolase A and C are expressed about equally.
There is a high degree of homology between aldolase A and C.
Defects in ALDOB cause hereditary fructose intolerance. [provided
by RefSeq].
- Bouteldja, N., et al. J. Inherit. Metab. Dis. 33(2):105-112(2010)
- Coffee, E.M., et al. J. Inherit. Metab. Dis. 33(1):33-42(2010)
- Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)
- Davit-Spraul, A., et al. Mol. Genet. Metab. 94(4):443-447(2008)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat
This ALDOB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-60 amino acids from the N-terminal region of human ALDOB.
229
Fructose-bisphosphate aldolase B
ALDOB
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
39 kDa
P05062
113611
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Obesity,Signal Transduction
P05062
Optimal dilutions for each application to be determined by the researcher.