Further Information
Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1
For WB starting dilution is: 1:1000
EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. A prototype member of the type 1 receptor tyrosine kinases, EGFR is encoded by the cellular oncogene cerbB1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
- Aifa, S., et al., Exp. Cell Res. 302(1):108-114 (2005).
- Adams, T.E., et al., Growth Factors 22(2):89-95 (2004).
- Ichinose, J., et al., Biochem. Biophys. Res. Commun. 324(3):1143-1149 (2004).
- Kuribayashi, A., et al., Endocrinology 145(11):4976-4984 (2004).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse
This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 847-876 amino acids from human EGFR.
1956
Epidermal growth factor receptor
EGFR
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
134 kDa
P00533
2811086
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Signal Transduction
P00533
Optimal dilutions for each application to be determined by the researcher.