ProSci

PARP3 Antibody

Product Code:
 
PSI-60-975
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in K562,MDA-MB453,NCI-H292,A549,293,Hela,CEM,NCI-H460 cell line and human nomal uterus tissue lysates (35ug/lane).
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Western blot analysis in K562,MDA-MB453,NCI-H292,A549,293,Hela,CEM,NCI-H460 cell line and human nomal uterus tissue lysates (35ug/lane).

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PSI-60-975-400ul400ul£626.00
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This product comes from: United States.
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Further Information

Additional Names:
Poly [ADP-ribose] polymerase 3, PARP-3, hPARP-3, ADP-ribosyltransferase diphtheria toxin-like 3, ARTD3, IRT1, NAD(+) ADP-ribosyltransferase 3, ADPRT-3, Poly[ADP-ribose] synthase 3, pADPRT-3, PARP3, ADPRT3, ADPRTL3
Application Note:
For WB starting dilution is: 1:1000
Background:
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PARP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-126 amino acids from the N-terminal region of human PARP3.
NCBI Gene ID #:
10039
NCBI Official Name:
Poly [ADP-ribose] polymerase 3
NCBI Official Symbol:
PARP3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
Q9Y6F1
Protein GI Number:
224471880
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q9Y6F1
User NOte:
Optimal dilutions for each application to be determined by the researcher.