ProSci

NYREN18 Antibody

Product Code:
 
PSI-61-405
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 3
Antibody is used in Western blot to detect NYREN18 in 293 cell lysate.
2 / 3
Western blot analysis of NUB1 using NYREN18 Antibody.293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NUB1 gene (Lane 2).
3 / 3
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Antibody is used in Western blot to detect NYREN18 in 293 cell lysate.
Western blot analysis of NUB1 using NYREN18 Antibody.293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NUB1 gene (Lane 2).

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PSI-61-405-400ul400ul£626.00
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Further Information

Additional Names:
NEDD8 ultimate buster 1, Negative regulator of ubiquitin-like proteins 1, Renal carcinoma antigen NY-REN-18, NUB1, NYREN18
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100
Background:
NYREN18 is a specific down-regulator of the NEDD8 conjugation system. It recruits NEDD8 and its conjugates to the proteasome for degradation. It also interacts with PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome.
Background References:
  • Tanaka, T., et al., J. Biol. Chem. 278(35):32905-32913 (2003).
  • Akey, D.T., et al., Hum. Mol. Genet. 11(22):2723-2733 (2002).
  • Kito, K., et al., J. Biol. Chem. 276(23):20603-20609 (2001).
  • Scanlan, M.J., et al., Int. J. Cancer 83(4):456-464 (1999).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This NYREN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 513-542 amino acids from the C-terminal region of human NYREN18.
NCBI Gene ID #:
51667
NCBI Official Name:
NEDD8 ultimate buster 1
NCBI Official Symbol:
NUB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
71 kDa
Protein Accession #:
Q9Y5A7
Protein GI Number:
37154888
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle
Swissprot #:
Q9Y5A7
User NOte:
Optimal dilutions for each application to be determined by the researcher.