ProSci

Transglutaminase Antibody

Product Code:
 
PSI-63-220
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of TGM2 using rabbit polyclonal using 293 cell lysates (2 ug/lane) either nontransfected (c) or transiently transfected with the TGM2 gene (Lane 2).
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Western blot analysis of TGM2 using rabbit polyclonal using 293 cell lysates (2 ug/lane) either nontransfected (c) or transiently transfected with the TGM2 gene (Lane 2).

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PSI-63-220-400ul400ul£626.00
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Further Information

Additional Names:
Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2, TGM2
Application Note:
For WB starting dilution is: 1:1000
Background:
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. TGM2 acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. It has been identified as the autoantigen implicated in celiac disease.
Background References:
  • Porzio,O., Hum. Mutat. 28 (11), 1150 (2007)
  • Parsons,A.C., AmDermatopathol 29 (5), 433-436 (2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Transglutaminase (TGM2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 413-442 amino acids from the Central region of human Transglutaminase (TGM2).
NCBI Gene ID #:
7052
NCBI Official Name:
Protein-glutamine gamma-glutamyltransferase 2
NCBI Official Symbol:
TGM2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
77 kDa
Protein Accession #:
P21980
Protein GI Number:
20141877
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle,Immunology,Obesity,Signal Transduction
Swissprot #:
P21980
User NOte:
Optimal dilutions for each application to be determined by the researcher.