ProSci

LINGO1 Antibody

Product Code:
 
PSI-62-794
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of LINGO1 Antibody in mouse cerebellum tissue lysates (35ug/lane)
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Western blot analysis of LINGO1 Antibody in mouse cerebellum tissue lysates (35ug/lane)

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PSI-62-794-400ul400ul£626.00
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Further Information

Additional Names:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat and immunoglobulin domain-containing protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, LINGO1, LERN1, LRRN6A
Application Note:
For WB starting dilution is: 1:1000
Background:
LINGO1 is a functional component of the Nogo receptor signaling complex(RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. It is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.
Background References:
  • Inoue,H., Proc. Natl. Acad. Sci. U.S.A. 104 (36), 14430-14435 (2007)
  • Satoh,J., Neuropathol. Appl. Neurobiol. 33 (1), 99-107 (2007)
  • Mosyak,L., J. Biol. Chem. 281 (47), 36378-36390 (2006)
  • Mi,S., Nat. Neurosci.(3), 221-228 (2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Monkey, Mouse
Immunogen:
This LINGO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 amino acids from the N-terminal region of human LINGO1.
NCBI Gene ID #:
84894
NCBI Official Name:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
NCBI Official Symbol:
LINGO1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
70 kDa
Protein Accession #:
Q96FE5
Protein GI Number:
74760819
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Neuroscience
Swissprot #:
Q96FE5
User NOte:
Optimal dilutions for each application to be determined by the researcher.