ProSci

TGIF Antibody

Product Code:
 
PSI-62-791
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of anti- in Y79 cell line lysates (35ug/lane).
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Western blot analysis of anti- in Y79 cell line lysates (35ug/lane).

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PSI-62-791-400ul400ul£626.00
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Further Information

Additional Names:
Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF
Application Note:
For WB starting dilution is: 1:1000
Background:
TGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.
Background References:
  • Pertile,K.K., Invest. Ophthalmol. Vis. Sci. 49 (1), 49-54 (2008)
  • Chavarria-Siles,I., Mol. Psychiatry 12 (11), 1033-1041 (2007)
  • Ferrand,N., FASEB J. 21 (2), 488-496 (2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken, Mouse
Immunogen:
This TGIF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human TGIF.
NCBI Gene ID #:
7050
NCBI Official Name:
Homeobox protein TGIF1
NCBI Official Symbol:
TGIF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
43 kDa
Protein Accession #:
Q15583
Protein GI Number:
215274200
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle,Neuroscience,Signal Transduction
Swissprot #:
Q15583
User NOte:
Optimal dilutions for each application to be determined by the researcher.