Further Information
Poly [ADP-ribose] polymerase 1, PARP-1, ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, PARP1, ADPRT, PPOL
For WB starting dilution is: 1:1000
This gene encodes a chromatin-associated enzyme,
poly(ADP-ribosyl)transferase, which modifies various nuclear
proteins by poly(ADP-ribosyl)ation. The modification is dependent
on DNA and is involved in the regulation of various important
cellular processes such as differentiation, proliferation, and
tumor transformation and also in the regulation of the molecular
events involved in the recovery of cell from DNA damage. In
addition, this enzyme may be the site of mutation in Fanconi
anemia, and may participate in the pathophysiology of type I
diabetes.
- Majewski, P.M., et al. J. Biol. Chem. 285(45):34828-34838(2010)
- Kim, M., et al. Cancer Sci. 101(11):2436-2442(2010)
- Dong, Y., et al. Cancer Res. 70(20):8088-8096(2010)
- Krishnakumar, R., et al. Mol. Cell 39(5):736-749(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Hamster, Mouse, Rat
This PARP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-87 amino acids from the N-terminal region of human PARP1.
142
Poly [ADP-ribose] polymerase 1
PARP1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
113 kDa
P09874
130781
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle,Obesity
P09874
Optimal dilutions for each application to be determined by the researcher.