Further Information
Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, PCGF2, MEL18, RNF110, ZNF144
For WB starting dilution is: 1:1000
The protein encoded by this gene contains a RING finger
motif and is similar to the polycomb group (PcG) gene products. PcG
gene products form complexes via protein-protein interaction and
maintain the transcription repression of genes involved in
embryogenesis, cell cycles, and tumorigenesis. This protein was
shown to act as a negative regulator of transcription and has tumor
suppressor activity. The expression of this gene was detected in
various tumor cells, but is limited in neural organs in normal
tissues. Knockout studies in mice suggested that this protein may
negatively regulate the expression of different cytokines,
chemokines, and chemokine receptors, and thus plays an important
role in lymphocyte differentiation and migration, as well as in
immune responses.
- Jung, J.H., et al. Biochem. Biophys. Res. Commun. 400(4):523-530(2010)
- Zhang, X.W., et al. Mol. Cancer 9, 40 (2010) :
- Wang, W., et al. Int. J. Cancer 125(12):2836-2843(2009)
- Zhang, J., et al. Biochem. Biophys. Res. Commun. 375(2):252-255(2008)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This PCGF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-150 amino acids from the Central region of human PCGF2.
7703
Polycomb group RING finger protein 2
PCGF2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
38 kDa
P35227
462585
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle,Signal Transduction
P35227
Optimal dilutions for each application to be determined by the researcher.