ProSci

RFFL Antibody

Product Code:
 
PSI-60-548
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in A2058 cell line lysates (35ug/lane).
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Western blot analysis in A2058 cell line lysates (35ug/lane).

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PSI-60-548-400ul400ul£626.00
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Further Information

Additional Names:
E3 ubiquitin-protein ligase rififylin, 632-, Caspase regulator CARP2, Caspases-8 and -10-associated RING finger protein 2, CARP-2, FYVE-RING finger protein Sakura, Fring, RING finger and FYVE-like domain-containing protein 1, RING finger protein 189, RING finger protein 34-like, RFFL (HGNC:24821), RNF189, RNF34L
Application Note:
For WB starting dilution is: 1:1000
Background:
RFFL has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
Background References:
  • Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
  • Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
  • Newton-Cheh, C., et al. Nat. Genet. 41(4):399-406(2009)
  • Liao, W., et al. Curr. Biol. 18(9):641-649(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This RFFL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human RFFL.
NCBI Gene ID #:
117584
NCBI Official Name:
E3 ubiquitin-protein ligase rififylin
NCBI Official Symbol:
RFFL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa
Protein Accession #:
Q8WZ73
Protein GI Number:
74760639
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q8WZ73
User NOte:
Optimal dilutions for each application to be determined by the researcher.