Further Information
Killer cell immunoglobulin-like receptor 2DS2, CD158 antigen-like family member J, MHC class I NK cell receptor, NK receptor 183 ActI, Natural killer-associated transcript 5, NKAT-5, p58 natural killer cell receptor clone CL-49, p58 NK receptor CL-49, CD158j, KIR2DS2, CD158J, NKAT5
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Killer cell immunoglobulin-like receptors (KIRs) are
transmembrane glycoproteins expressed by natural killer cells and
subsets of T cells. The KIR genes are polymorphic and highly
homologous and they are found in a cluster on chromosome 19q13.4
within the 1 Mb leukocyte receptor complex (LRC). The gene content
of the KIR gene cluster varies among haplotypes, although several
'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of
extracellular immunoglobulin domains (2D or 3D) and by whether they
have a long (L) or short (S) cytoplasmic domain. KIR proteins with
the long cytoplasmic domain transduce inhibitory signals upon
ligand binding via an immune tyrosine-based inhibitory motif
(ITIM), while KIR proteins with the short cytoplasmic domain lack
the ITIM motif and instead associate with the TYRO protein tyrosine
kinase binding protein to transduce activating signals. The ligands
for several KIR proteins are subsets of HLA class I molecules;
thus, KIR proteins are thought to play an important role in
regulation of the immune response.
- Biassoni, R., et al. J. Exp. Med. 183(2):645-650(1996)
- Dohring, C., et al. Immunogenetics 44(3):227-230(1996)
- Wagtmann, N., et al. Immunity 2(5):439-449(1995)
- Colonna, M., et al. Science 268(5209):405-408(1995)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This KIR2DS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-65 amino acids from the Central region of human KIR2DS2.
100132285, 115653, 3804
Killer cell immunoglobulin-like receptor 2DS2
KIR2DS2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
34 kDa
P43631
13124793
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology
P43631
Optimal dilutions for each application to be determined by the researcher.