Further Information
Optineurin, E3-147K-interacting protein, FIP-2, Huntingtin yeast partner L, Huntingtin-interacting protein 7, HIP-7, Huntingtin-interacting protein L, NEMO-related protein, Optic neuropathy-inducing protein, Transcription factor IIIA-interacting protein, TFIIIA-IntP, OPTN, FIP2, GLC1E, HIP7, HYPL, NRP
For WB starting dilution is: 1:1000
This gene encodes the coiled-coil containing protein
optineurin. Optineurin may play a role in normal-tension glaucoma
and adult-onset primary open angle glaucoma. Optineurin interacts
with adenovirus E3-14.7K protein and may utilize tumor necrosis
factor-alpha or Fas-ligand pathways to mediate apoptosis,
inflammation or vasoconstriction. Optineurin may also function in
cellular morphogenesis and membrane trafficking, vesicle
trafficking, and transcription activation through its interactions
with the RAB8, huntingtin, and transcription factor IIIA proteins.
Alternative splicing results in multiple transcript variants
encoding the same protein.
- McDonald, K.K., et al. J. Hum. Genet. 55(10):697-700(2010)
- Cheng, J.W., et al. Med. Sci. Monit. 16 (8), CR369-CR377 (2010) :
- Albagha, O.M., et al. Nat. Genet. 42(6):520-524(2010)
- Maruyama, H., et al. Nature 465(7295):223-226(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Rat
This OPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-96 amino acids from the Central region of human OPTN.
10133
Optineurin
OPTN
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
66 kDa
Q96CV9
317373403
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology,Neuroscience,Signal Transduction
Q96CV9
Optimal dilutions for each application to be determined by the researcher.